Transposable elements (TEs), such as retrotransposons and endogenous retroviruses, are increasingly recognized for their important roles in genome function and impact on disease development. Residing ...

A representation of hybrid quantum computing for drug design. Ghazi Vakili et al. present a hybrid quantum–classical generative model to design molecules to inhibit KRAS activity. Two candidates are ...

Luebbert et al. present a method to detect viral sequences in bulk and single-cell transcriptomic data using conserved amino acid domains instead of annotated reference genomes.

Transverse section of a hind leg muscle of a 6-month-old mouse showing GFP gene expression following delivery by an adeno-associated virus 8 vector (tibia and fibula bones and muscle cell nuclei are ...

An illustration of lipid nanoparticles (green circles) targeting the lung, designed using neural networks. Witten et al. present a method (LiON) using neural networks for lipid discovery and ...

Optimizing guide RNA design for Cas13. With data from massively parallel screens, Wessels et al. develop computational models to identify optimal guide RNAs for the RNA-targeting CRISPR enzyme Cas13d.

Single-cell proteomics maps protein dynamics in the developing human brain.

Increasing access to biotech products for animal agriculture in Sub-Saharan Africa through partnerships José de la Fuente Christian Gortázar Justus Rutaisire ...

A model of two zinc-finger nucleases bound to DNA overlaid on an image of a metaphase chromosome spread. The side chains shown are key to the dimer interface of the cleavage domains, according to ...

A depiction of a cell-based sensor for cancer. Aalipour et al. engineer macrophages to express reporter proteins traceable in the blood when they activate the arginase-1 promoter. See Aalipour et al.

Engineered cellular immunotherapy shows great potential for treating autoimmune diseases. Payne and colleagues review emerging clinical data of the most recently developed technologies. Hughes and ...

Artwork by Pamela Goode. Neuron- and glia-like cells derived from induced pluripotent stem cells promise tractable, individualized human models of Alzheimer's, Parkinson's and amyotrophic lateral ...