Cell-free protein synthesis (CFPS) represents a transformative technology in which the molecular machinery of transcription and translation is extracted from living cells and employed in a controlled ...

Many biological functions are regulated by the switching on and off of mechanisms triggered by the matching of a keyhole ...

Ribosomes are fundamental molecular machines that translate mRNA sequences into polypeptides, ensuring the proper synthesis of proteins essential to cellular function. However, the fidelity of protein ...

Proteoforms, the diverse molecular variants of proteins, are key to understanding cellular functions, disease mechanisms, and ...

The yeast Kluyveromyces lactis (K. lactis) could become a highly productive, sustainable, cost-effective energy source for cell-free protein synthesis (CFPS) as biopharmaceutical manufacturers strive ...

Under stress, animal cells pair inactive ribosomes into RNA-linked disomes. A ribosomal RNA “kissing loop” joins them, protecting ribosomes and reducing protein synthesis to conserve energy.<br /> ...

Scientists have identified a critical breakdown in the cellular machinery that produces proteins in aging brains.

Nerve cells have amazing strategies to save energy and still perform the most important of their tasks. Researchers from the University Hospital Bonn (UKB) and the University of Bonn as well as the ...

Ribosomes, the cell's protein-making factories, consume large amounts of energy as they build the proteins that keep cells alive and functioning. When cells experience stress—such as lack of nutrients ...

A newly developed luciferase-based reporter can detect problems in protein translocation and disulfide bond formation in the endoplasmic reticulum (ER). Inspired by natural mechanisms found in ...

Proteins, the pillars of cellular function, often assemble into 'complexes' to fulfill their functions. A study reveals why this assembly often begins during the very process of protein synthesis or ...