Nature

Analysis of the Lung Pathology and Alveolar Macrophage Function in the Acid Sphingomyelinase–Deficient Mouse Model of Niemann-Pick Disease

Types A and B Niemann-Pick disease (NPD) are lipid storage diseases caused by the deficient activity of the lysosomal enzyme, acid sphingomyelinase (ASM). Type B NPD is associated with progressive ...
Nature

Small alveolar macrophages are infected preferentially by HIV and exhibit impaired phagocytic function

HIV-1-infected persons are at higher risk of lower respiratory tract infections than HIV-1-uninfected individuals. This suggests strongly that HIV-infected persons have specific impairment of ...
News Medical

Immunoproteasome inhibits repair function of alveolar macrophages

Scientists of Helmholtz Zentrum München, a partner in the German Center for Lung Research (DZL), have observed that the immunoproteasome inhibits the repair function of alveolar macrophages. This ...
GEN

Stem Cells that Rebuild Alveoli After Acute Respiratory Distress Syndrome Identified

Lung damage causes proliferation of P63-expressing cells in bronchioles, migration to damaged tissue, and regeneration of alveoli. Scientists have identified a subset of stem cells in rodents and in ...
The New England Journal of Medicine

Pulmonary Alveolar Proteinosis

In acquired pulmonary alveolar proteinosis, lipids and proteins accumulate within the alveoli because alveolar macrophages cannot catabolize surfactants. Surprisingly, alveolar macrophages require ...