Bone marrow adipocytes (BMAds) are situated within the bone microenvironment, in close proximity to bone cells, vascular structures, and hematopoietic tissues. The shift of bone marrow stromal/stem ...

Metabolic diseases such as obesity, fatty liver, and insulin resistance are rapidly increasing worldwide, but fundamental methods to regulate the process of fat formation remain limited. In particular ...

CIDEC/FSP27 promotes obesity-related AAA by modulating adipocyte-derived CCL2 secretion and macrophage infiltration through JNK signaling. Abdominal aortic aneurysm (AAA) is a degenerative lesion ...

The prevalence of obesity worldwide has led to an increase in the risk of metabolic diseases and socio-economical burdens. Brown adipose tissue (BAT) has been established as a promising therapeutic ...

An international team led by National University of Singapore researchers has linked secondary lymphedema to excessive cholesterol buildup inside skin and around lymphatic vessels. Excess cholesterol ...

In a recent review published in the journal Nutrients, researchers explored how the dysregulation of gut microbiota in obesity impacts adipose tissue (AT) metabolism through direct and indirect ...

Uncovering the mystery of why individuals born with mutations in the gene that encodes HSL—the cytosolic enzyme that releases energy from fat—lose fat instead of gaining it, Dominique Langin, PhD, ...